The Secret of Cancer:
“Short-Circuit” in the Photon Switch.
Change in the medical world-view of tumorology—The rational Cell
Symbiosis Therapy concept
In Western countries, every third person suffers from some form of cancer,
and every fourth person dies of it. The prognoses of the WHO state that by
the year 2050 half of all mortalities will be due to a cancerous disease.
According to the prevailing cancer theories chance defects (mutations) in the
DNA in the nucleus, which are regarded as irreparable, are considered to be
the primary cause of the disease. Standard therapy in oncology (operations,
chemotherapy and/or radiation therapy) is based on this assumption. The
cure rates of cancer (minimum of 5 years survival after diagnosis) are given as
being 45% (22% surgical treatment, 12% radiation therapy, 5% chemotherapy,
6% combined standard therapies). 60-70% of patients with incurable cancer
are palliatively treated with radiation therapy, 50% with chemotherapy and
less than 1% of the patients are treated surgically (EU data, 2003). In the
USA, for instance 20% of the overall health budget is spent annually on
chemotherapy for cancer patients.
The Nobel Prize winner Professor Watson, who together with Crick
discovered the double helix of DNA in the nucleus, the most prominent
promoter of the 1971 “War on Cancer” succinctly declared in 2003: “First
we have to understand cancer before we can cure it.”
The background to this sobering thought after decades of most
intensive research efforts and a massive capital injection is the fact that the
classic mutation theory of oncogenesis has been forever shaken by newer
research. Under the mutation theory a tumor colony develops from a single
“degenerated” body cell that through uncontrolled division is thought to
pass on identical DNA defects to all daughter cells. However, it has become
apparent that each individual cancer cell, even within the same tumor of a
patient, features genetically varies.
The internationally respected cancer researchers Professor Weinberg from
the MIT in Cambridge, USA and Professor Hahn from the Dana Farber
Cancer Research Center in Boston, both supporters of the classic mutation
theory, published in 2002 an overview of the ostensibly still puzzling six
insiduous “acquired capabilities” of cancer cells. These attributes include the
ability to:
1. resist exogenous growth-inhibitory signals
2. generate their own mitogenic signals
3. bypass apoptosis
4. acquire vasculature
5. gain potential immortality
6. invade and metastasize
The “Cell Dyssmybiosis Concept” (Kremer 2001) explained for the first time
the six “acquired capabilities” of cancer cells as an evolutionary-biologically
programmed natural (albeit overregulated) protective switch of the divisionally
active human cells during permanent chronic cell stress. The origin of this
concept was the evolutionary-biological discovery that humans owe their
biological existence, like all nucleated single—or multi-cellular creatures
(eukaryotes), to a unique act of integration deep in the history of evolution.
Roughly 2 billion years ago two unicellular organisms without nuclei from
the archaea and bacteria domains fused to form a new single cell type that
is now termed protista. Comprehensive comparative sequence analyses
regarding the genetic make-up and specific proteins of archaea, bacteria,
and a multitude of eukaryotic organisms (including humans), produced an
astonishing result: about 60% of the genes in a human nucleus originate from
the primeval archaea (A genome) the remaining genes having a bacterial
origin (B genome), which in particular in the nucleus are delegated by the
bacterial endosymbionts that have survived up until today in all human cells
as mitochondria (on average 1,500 per cell).
There is a controlled division of labor between the A and B genomes: the A
genome dominates the late cell division phases, while the B genome drives
the early cell division phase and the functions of the various differentiated
cell types.
From these fundamental cellular biological facts, and integrating a large
number of new experimental and clinical research data, the cell symbiosis
concept leads to the following conclusions about oncogenesis and cancer
therapy:
1. There is a controlled toggle-switch between the mitochondria and both
nuclear subgenomes.
2. Transformation to cancer cells is a functional (not structural) failure of
this toggle-switch, after the divisional phase cells are no longer sufficiently
able to switch back to the differentiated cell performance phases
3. The cause of this permanent functional failure is the gradual deficiency
of one of the central functions of mitochondria, namely to supply ca.
90% of the “universal energy-storing and energy-transporting molecule”
adenosine triphosphate (ATP) for practically all biosyntheses and
metabolic processes. Under normal circumstances roughly one’s body
weight of ATP has to be synthesized and then broken up every day. ATP
cannot be stored and the actual stock in human beings is enough for only
5 seconds. When the mitochondrial functions are disturbed, cancer cells
intermittently or permanently revert to the archaic form of ATP synthesis
in the cytoplasm (glycolysis) with, potentially, up to a 20-fold increase
in the glucose turnover at the cost of the organism as a whole (cachexia
resulting from the forced degradation, especially of muscle proteins for
the benefit of carbon intermediary products for glycolysis, is one of the
most frequent causes of death in cancer patients).
4. Hitherto perceptions about the synthesis and function of ATP molecules,
the basis of all cellular biological medical theories, are, however,
objectively false. ATP has 3 molecule groups: 1 base adenine ring
molecule that absorbs the light quanta at near-ultraviolet levels of 270
nm, 1 sugar molecule with 5 carbon atoms as well as a—molecule string
with 3 phosphate groups. The current dogma, based on a theory formed
more than 60 years ago by the later Nobel Prize winner Lippmann, is that
electron energy is transferred in the respiratory chains of mitochondria
(of which there are literally thousands in every mitochondrion as
shown by EM photographs) on discharge of “energy-rich” electrons
from nutrients via a kind of electrochemical battery, to protons which
for their part drive ATP synthesis energetically and store their surplus
energy in the phosphate bonds of ATP. These “energy-rich” phosphate
bonds of ATP transported into the cytoplasm then release this stored
energy via hydrolysis mainly to maintain the energetic processes of cell
metabolism. Biochemical experiments have clearly shown, however, that
the phosphate bonds of ATP are not especially rich in energy and that,
upon hydrolysis, only heat energy is released that can at the most be
used for heat production by isotherm cells (constant cell temperature).
The fundamental question of the actual mechanism for the acquisition
of cell energy remains unanswered. This fact explains the predominant
failure of cancer prevention and therapy up until now.
5. Biochemistry and medical science have failed to this day to explain the
function of the adenine groups of ATP, as no biochemical reaction with
this adenine ring molecule is shown. However, an understanding can
be gained, within the framework of the cell symbiosis concept, from
the biophysical attributes of light absorption of the adenine group. All
essential components of mitochondrial cell respiration are light-absorbing
molecules with characteristic “frequency windows” of absorption maxima
from near the UV spectrum to the longer wave yellow/orange spectral
range of visible light up to ca. 600nm. Yet the source of the electromagnetic
energy is not sunlight. In fact a low frequency pulsating electromagnetic
field is induced by the constant flow of uncoupled, paramagnetically
aligned electrons in the respiratory organelles. The electromotive power
generated by this process is catalytically enormously strengthened by
the enzyme complexes of the respiratory chain (acceleration factor of
1017). This effects an interaction between the electrons and the protons
likewise aligned parallel to the induced magnetic field dependent on
the strength of the magnetic field between the antiparallelly aligned
electrons and protons. This process produces a quantum dynamic transfer
of information via photonic energy exchange. The ultimate source of
photons are fluctuations of resonance frequencies of the physical vacuum
(zero-point energy field). The transferred information is stored in the
spin of the protons that proceed to the ATP synthesis complex via
proton gradients. There, the resonance information is transferred by a
unique rotation system to the adenine group of ATP whose electrons can
move freely in the alternating double bonds of the ring molecules. The
ATP serves as an “molecular antenna” for the reception and relaying of
resonance information from the “morphogenetic field.” Human symbiosis
is consequently not a heat power machine but a light frequency-modulated
information-transforming medium. All the time this cell symbiosis is
resonance coupled with the lowest, not-yet-materialized energy status
(the physical vacuum as an inexhaustible “global information pool”).
6. In oncogenesis, for a diversity of reasons, there is a functional disturbance
especially to the 4th enzyme complex of the respiratory chain. The task
of this complex, according to conventional opinions, is to transfer the
inflowing electrons to molecular oxygen at the end of the respiratory chain
and thus reduce it to water. In the cell symbiosis concept, however, the
crucial factor is that, in reducing O2 to water, completed electron couplings
induce an antimagnetic impulse, and the electromagnetic alternating field
for resonance information transfer switches on and off at an extremely
fast periodic time interval (in picoseconds). If the electron flows to O2,
however, are permanently disturbed then a failure in the modulation of
ATP occurs and increasing numbers of oxygen and other radicals form
that can attack and damage the macromolecules (nucleic acids, proteins,
The Secret of Cancer and the Concept of Cell Symbiosis Therapy 503
lipids, carbohydrates). In order to prevent this danger the key enzyme
hemoxygenase upregulates. This enzyme uses O2 as cofactor for the
production of carbon monoxide (CO). In cases of long-term surplus
production CO gas has crucial effects on cancer cell transformation:
• CO gas effects a characteristic phase shifting of the absorption
of visible light from components of the respiratory chain and as a
result “short-circuits” the photon switch for the modulation of the
information transfer to the mitochondrial ATP.
• CO gas activates in the cytoplasm certain regulator proteins for the
stimulation of the cell division cycle also without external growth
signals (see above: 1st “acquired capability”).
• CO gas effects via enzymatic overactivation of the important
secondary messenger substance cyclic guanosine monophosphate
(cGMP) the inhibition or blockade of communication between
neighboring cells (2nd “acquired capability” of cancer cells).
• CO gas blocks programmed cell death by bonding onto the bivalent
iron in important key enzymes (3rd “acquired capability” of cancer cells).
The result is a polar program reversal: The transformed cancer cells remain
trapped, dependent on the degree of malignancy, in a continuous cell division
cycle and can not switch back to the differentiated cell performances of the
respective cell types without biological compensatory aid. According to
recent clinical knowledge the cancer cells become especially malignant and
massively disperse metastatic cells when the O2 supply to tumor cells via
capillary blood vessels is impeded. In these cases chemotherapy and radiation
treatment are no longer effective as without the presence of molecular oxygen
programmed cell death of the cancer cells can no longer be induced. In
this situation cancer patients are considered incurable by oncologists using
standard cancer therapy.
• The cell symbiosis concept postulates that when the cofactor O2 is
deficient, then the even more effective cyanide gas (HCN) is formed
instead of CO. HCN is in humans the strongest mitochondrial
respiratory poison and produces an even stronger phase switching
of the absorption of visible light, probably by the well known
inhibition of the reduction of trivalent irons to bivalent irons of
certain hemocytochromes of the respiratory chain. This hypothesis
can support the evolutionary-biological views of the cell symbiosis
concept as cancer cells regress de facto to unicellular organisms (as
a result of the loss of cell-to-cell communication with neighboring
tissue cells) and that is why they behave like “parasitic cells” (4th, 5th,
and 6th “acquired capability” of cancer cells). In this sense, cancer
cells represent a regression to the early eukaryotic stage of a colony
of protist cells, and so use the conserved archive of evolution in
human nuclear genomes as a strategy of survival, depending on the
actual given milieu conditions of the individual cancer cells (for the
individual genetic variations, see above).
7. In 2003, American cancer researchers confirmed a functional disruption
of cancer cells in the 4th complex of the respiratory chain despite
simultaneously intact messenger RNA and intact mitochondrial DNA,
without being able to explain this phenomenon. However, at the end of
2002 a cancer research group from Helsinki University, after many years of
animal experiments and clinical studies, were able to exactly document for
the first time—using electron microscopes and mass spectrometers—that
the transformation to cancer cells is actually caused by the loss of control
of the cell division cycle of the mitochondria.
The clinical research team could demonstrate that the tumor cells after a
relatively short time had re-programmed to intact, normal differentiated cells
without signs of programmed cell death by using a particular experimentally
mediated bioimmunological compensation therapy on various human cancer
diseases. These patients under conventional tumor therapy had a survival
status of on average less than 12 months. In 2003 researchers from the
Anderson Cancer Research Center of the University of Texas in Houston
published the first wide-ranging overview about the hundreds of animal
experiments on the effects of curcumin, the active ingredient of turmeric
(Curcuma longa, from the ginger family, biochemically, curcumin I from the
molecular family of polyphenols, also termed bioflavonoids, synthesized
from plants) on cancer cells and metastases. The researchers were amazed to
discover that curcumin effectively inhibited nearly all signal paths in tumor cells
and metastases.
The researchers were unable to provide an explanation of this wide-ranging
effect. The actions of curcumin can, however, be explained if you know that
curcumin in the violet spectral range of visible light absorbs with nearly
the same wavelength—415 nm—as the electron-transferring molecule
cytochrome c that is more rapidly broken up by the protective enzyme
hemoxygenase in cancer cells. In cancer cells curcumin, so to say, bridges the
III and IV complex photon switch “short-circuit” of the respiratory chain in
The Secret of Cancer and the Concept of Cell Symbiosis Therapy 505
mitochondria and thus normalizes the information transfer for maintaining
modulation of ATP.
The quoted research data show that (in opposition to the prevailing
cancer theories of supposedly irreparable gene defects in the nucleus) the
demonstrated functional disruptions of the transfer of information in
cell symbionts can be re-normalized by means of an adequate biological
compensation therapy. The concept of cell symbiosis therapy (Kremer 2001)
derived from knowledge gained from cell symbiosis research has in the
meantime led to some spectacular therapeutic successes (in individual cases
even in cancer diseases that had been declared incurable). There is a broad
spectrum of classes of substances responding to natural light available and
the potential is by no means exhausted. What is desperately needed, however,
is a comprehensive overhaul of the current state of research with the aim of
developing optimized therapeutic formulations and to make them available for
clinical and therapeutic practice. Admittedly, achieving this purpose through
an interdisciplinary research group within the established health system is
not to be expected in the foreseeable future, as conventional medical science
has largely remained stuck in the one-sided thermodynamic energy concepts
of the 19th Century.
(First published in Townsend Letter Aug. /Sept. 2007)